The Aqueous IFD and Solvent IFD microfiltration devices are in-line filter/degassers. As the name implies, the Aqueous IFD provides pure filtration of aqueous based HPLC mobile phases while the Solvent IFD is used with organically based HPLC mobile phases. Specifically, the Aqueous IFD is designed to work with mobile phases containing at least 20% of the aqueous component. The filter media used in this filter is nylon; for the Solvent IFD it is polypropylene. The devices employ a polypropylene housing, the circumference of which is sealed by a security ring.